NOT KNOWN DETAILS ABOUT PKRRATING

The activated enzyme then phosphorylates its main substrate, the translational initiation element eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to some conserved family of 4 protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in response to various stimuli12, triggering the built-in strain resp